Decellularised tissue extracellular matrices (dECMs) can be finely minced and solubilised to obtain homogeneous hydrocolloids.
We have optimised a pepsin enzymatic digestion treatment to obtain homogeneous liver dECM pre-gel solutions that can form stable ECM gels via thermal gelation at 37 °C. This biocompatible crosslinking can occur even in presence of cells obtaining 3D cell-laden ECM hydrogels for a variety of applications ranging from in-vitro models to drug testing.
Contact info:
Ludovica CACOPARDO
Related publications:
In preparation.