This course will guide students in the design of cell and tissue-based systems for application to the development of in vitro models, artificial organs and delivery systems using technology based on stem cells, organoids, smart materials and smart fabrication.

Starting from a quantitative description of cell, tissue and organ assembly, and of their requirements in terms of resources, microenvironmental conditions, cooperation and competition, the course  covers fundamental design principles. It also provides a comprehensive overview of stem cell, organoid and on-chip technology as well as mathematical models of self-assembly, growth and differentiation. Project work will include design and simulation of in vitro models.